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Senior Director of Bioprocess Technology & Engineering - BPD

Location Gaithersburg, Maryland, United States Job ID R-114186 Date posted 15/07/2021

You can impact the world with science! Join us so that we can provide lifesaving treatments to patients around the world, including treatments and vaccines for COVID19.

As a Senior Director in Bioprocess Technology and Engineering, you would lead a team of people responsible for the design and control of bioreactors for mammalian cells, as well as the late-stage characterization of harvest and clarification. In addition, your team would be key contributors for the design of a high-cell density bioreactor that is at the heart of our next generation manufacturing platform. This responsibility includes the design and control of AMBR15, AMBR250, 3L, and pilot and commercial scale bioreactors. Your team would be responsible for a cohesive scale-up and scale-down strategy in support of the cell-culture process development group. You would also be expected to design and implement control strategies for all downstream operations using mechanistic models. The advanced process control would include virus inactivation, filtration, and chromatography.

You will have the possibility of leading a CMC team and sitting on a global clinical development team representing Biopharmaceutical Development.  

You will present at internal departmental and cross-functional meetings, as well as to CMOs. You would be expected to present at external symposia, as well as publish.

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.  This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. 

Summary of the group:

Bioprocess Technology and Engineering team works with development scientists to convert a process description into a working manufacturing process at sites all over the world. The team is responsible for the scale-up of cell-culture and harvest operations. The team supports some trouble shooting, especially related to scale-up, and usually early in the TT lifecycle. The team also supports Process Performance Qualification, and represents the development area to the manufacturing sites.

Main Duties & Responsibilities:

  • Design operation strategies for small and large scale bioreactors, including gassing, CO2 control, pH control
  • Oversee the characterization of harvest operations, tech transfer of harvest operations
  • Support large scale implementation of bioreactor and harvest operations
  • Interpret process descriptions to operate in large scale manufacturing sites
  • Perform facility fit exercises
  • Recommend solutions to development or to the site to mitigate against scale up risks or facility fit issues

Education & Experience Requirements:

Bachelor’s degree and 20+ years OR Master’s degree and 17+ years of Ph.D. and 13+ years of experience in STEM related fields, including chemical, mechanical, civil, biochemical, electrical engineering, physics, biophysics, biochemistry, chemistry, biology, mathematics, and computer science.

Required Skills:

  • People Leadership Skills (direct or as team lead)
  • Bioreactor or fermentation scale-up and scale down experience (up to 2000L ideally up to 12,000L)
  • Problem solving
  • Scientific reasoning
  • Bioprocess Development or process tech transfer
  • Understanding and translating process descriptions to fit in new manufacturing plants
  • Conversational and technical English

Desired Skills:

  • Engineering or scientific skills related to bioprocessing
  • Project management
  • Mechanistic modelling of downstream operations
  • Mechanistic modelling of bioreactor, filtration

Why AstraZeneca?

We are proud to work for AstraZeneca for many reasons. Most recently, we are proud of our development of a vaccine and antibodies to treat or prevent COVID19. During the pandemic, we have pledged to forgo any profit from these products! And we are making these products available globally! We are working incredibly hard on these and other projects, and need you to join us so we can be successful.

AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Check out our landing page for more information on our BPD group  https://careers.astrazeneca.com/bpd

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

10000675 G ENCP R&D BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.