Scientist - Immunology
Here at AstraZeneca you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a Senior Scientist in Microbial Sciences in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.
The Microbial Sciences group at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re utilizing our expertise in microbiology and vaccines to enable novel approaches to prevent and treat infectious disease. We’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules and novel biologics platforms.
As a member of the Vaccine Immunology team, you will work as part of a team discovering and developing novel antibodies, technologies and vaccines for the prevention and/or treatment of viral infections in AstraZeneca’s infectious disease portfolio. The individual will be a well-organized and highly productive bench scientist who can design and execute experiments efficiently and interpret data in the context of multidisciplinary project teams. The position requires strong technical expertise in immunology and an ability to work in a fast-paced, matrix-structured work environment. He/she will have general knowledge of the fields of virology and cell biology.
Major Duties and Responsibilities:
• Design and execute vaccine immunogenicity studies in mice and other animal models, analyzing antibody responses and immune cells from various tissues.
• Perform cellular immunology assays such as characterization of vaccine specific T-cell and B-cell subsets and innate immune cells by intracellular cytokine staining and multi-parametric flow cytometry (FACS), immune cell-based assays etc.
• Perform infection challenge studies in mice and other animals using clinical and virologic endpoints
• Degree in immunology, cell biology or related subject
• Relevant experience in industry (preferred) or academia:
• M.S. with 2-5 years additional experience; B.S. with 5-8 years additional experience
• Technical knowledge of mammalian innate and adaptive immunity, human and animal viruses
• Technical knowledge of Immune cell culture and characterization (such as multicolor flow cytometry, ELISPOT, multiplex cytokine analysis and T & B cell epitope mapping)
• Technical knowledge of In vivo immunogenicity and infection/challenge models
• Strong organizational, written, and oral communication skills
• Knowledge of data analysis packages
• Ability to work in a team environment
• Experience working with multiple vaccine platforms (viral vector, RNA, DNA, nanoparticle) and adjuvants
• Experience working with wide range of viral pathogens
• Displays a general knowledge of biopharmaceutical research and development.
Supervision: Reports to Associate Principal Scientist, Vaccine Immunology, Microbial Sciences
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.