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Scientist I/II - Cell Therapy (CAR-T) - BPD

Location Gaithersburg, Maryland, United States Job ID R-077424 Date posted 03/16/2020

Has a good understanding of procedures relating to oncologic application of Adoptive Cell Therapy (ACT). Executes cell therapy experiments and projects through cross-functional interactions with Research, Analytical Development, and other functions within Biopharmaceutical Development. Is involved in strategic initiatives related to platform design and enhancements.  

Designs and conducts laboratory projects/experiments, develop methods, generate interpret and report scientific data. Competent in trouble shooting and theory. Designs and develops optimal manufacturing process solutions required to enable effective delivery of cell therapy products in the clinic.  Helps develop the tools to enable understanding of the process and product needed for clinical and commercial applications. 

Desired Skills:

  • Executes development research experiments independently by applying techniques of cellular biology, maintaining lab notebooks, and consistently summarizing and interpreting research findings in development reports and communicating results to team members.  Candidate will be involved in the interpretation of the data.  
  • Maintains understanding of product development and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed
  • Assesses and reports data, with little or no guidance, in a clear and concise manner, with a clear understanding of its implications within the overall context of product development
  • As an evolving subject matter expert in CAR-T field, provides technical instructions to the team where relevant
  • Shares relevant external published papers with peers
  • Communicates and shares information between distinct projects within the bioscience function and across other functions
  • Understanding of product development within a biopharmaceutical context
  • Uses knowledge of immunology, cellular engineering, T cell biology, and T cell therapy and exhibits extensive experience working with multiple gene transduction systems for immune cells
  • Understanding of biology supporting adoptive cellular immunotherapy as a therapeutic modality
  • Work effectively and collegially as a team member within a highly matrixed organizational structure and to be able to effectively articulate and communicate the lab findings to a diverse audience
  • Excellent communication skills and presentation skills 
  • Ability to work well in a collaborative manner, with a strong work ethic and an entrepreneurial spirit 
  • Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Education Requirements:

• Ph.D., Masters, or Bachelors degree in Chemical/Biochemical Engineering/Cell Biology / Immunology / Biochemistry/ Biotechnology/ Virology.
• Background in drug development in the biopharmaceutical industry

Scientist I: Bachelors degree and 10+ years of experience OR Masters degree and 8+ years of experience OR Ph.D and 0+ years of experience.

Scientist II: Bachelors degree and 13+ years of experience OR Masters degree and 10+ years of experience OR Ph.D and 3+ years of experience.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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