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Senior Scientist, Bioscience - High Throughput Biologics Screening

Location Gaithersburg, Maryland, United States Job ID R-094333 Date posted 12/22/2020

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

Antibody Discovery & Protein Engineering (ADPE) is responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

Main Duties & Responsibilities

We are seeking a skilled and highly motivated Senior Scientist to enhance our High Throughput Production & Screening (HTPS) capabilities of biologics. The successful candidate will play a critical role in a core group responsible for high-throughput cloning, expression & purification of antibody therapeutics on a microgram-to-milligram scale and be an advocate for utilizing various automation platforms. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, as well as analyze, interpret and present data to multidisciplinary project teams

  • Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects.
  • Execute high-throughput cloning, production and purification of protein therapeutics from bacterial or mammalian expression systems using process automation and liquid handling robotics.
  • Biochemical, biophysical and functional profiling of antibodies and recombinant antibody fragments.  
  • Ability to solve process development problems and implement improved procedures.

Education & Experience Requirements

PhD in Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with 2+ years of post-doctoral experience in antibody engineering and/or bispecific design.

Required Skills

  •  Experience in molecular and cell biology techniques, including; cloning, transfection and transduction methods.
  • Experience in expression, purification and biochemical/biophysical characterization of various antibody formats.
  • Experience in optimizing/troubleshooting affinity chromatographic techniques with a problem-solving mindset.
  • Experience in sample tracking and laboratory logistics software.
  • Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines.
  • Track record of scientific innovation as evidenced by scientific publications, patents and oral presentations at conferences.

Desired Skills

  • Experience in antibody discovery using one of several display-based technologies.
  • Experience in various imaging/multicolor flow cytometry-based instruments and data analysis programs.
  • Experience in tissue culture techniques and functional cell-based assay development.
  • Strong interpersonal and communication skills as well as the ability to work within teams.
  • Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management.

Why AstraZeneca

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

Where can I find out more

Check out our landing page for more information on our BPD group

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.