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Postdoctoral Fellow: Cancer cell and gene therapy

Location Gaithersburg, Maryland, United States Job ID R-157301 Date posted 19/01/2023

Postdoctoral Fellow: Cell and Gene Therapy for cancer treatment

Gaithersburg, MD (US)

Competitive Salary, Bonus & Benefits 

Do you have experience in molecular biology, stem cell biology, cell therapies, immunology, and/or animal models? Are you excited by the potential of new technologies in the cell and gene therapy arena to make a clinical impact in cancer treatment? Then this opportunity to combine your academic and industry career aspirations in our pioneering research laboratories at AstraZeneca might be the right one for you.

About AstraZeneca:

AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we are dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. There’s no better place to make a difference in medicine, patients, and society.

About the Postdoc Programme:

Bring your expertise, apply your knowledge, follow the science, and make a difference.

Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting, high-impact projects in a collaborative, engaging and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals, and make a difference to our patients.

This is a 3-year programme, with an initial 2-year period and 1-year, merit-based extension.

About the Opportunity:

We are looking for a Postdoctoral Fellow to join our Cell Therapeutics and Viral Technologies team, which sits within AstraZeneca R&D.  Our team has broad expertise in cell and gene therapies, with specific expertise in CAR T-cells, Tregs, stem cells, viral technologies, and tissue engineering.  Cell therapies are revolutionizing cancer treatment, but expanding the types of cancers that can be targeted by cell therapies require that these therapies can definitively differentiate cancer cells from healthy cells.  The major focus of this project will be the development of new tools to enable the specific targeting and destruction of cancers with cell therapies.  The project will require expertise in stem cell biology, immunology, molecular biology, cell therapies and testing in animal models.  We are looking for candidates who have some of these skills and who are committed to learning the additional skills required to enable the successful execution of the project.  Our team has approximately 35 members, and we collaborate broadly within Oncology R&D as well as other therapeutic areas within AstraZeneca.  The selected candidate will have the full support of the team, as well as access to the broad expertise and excellent facilities at AstraZeneca. 

We view the training of the candidate as a high priority output from this project.  Including broad support from the team, the candidate will receive mentorship from Dr Mike Doran, Director, and Dr Yasuhiro Ikeda, Senior Director, in the Department of Cell Therapeutics and Viral Technologies. AstraZeneca’s Postdoc’s are encouraged to publish and present their data at conferences; Dr Doran and Ikeda have extensive publication track records and have mentored and supported earlier career researchers who have pursued careers in academia and industry. 

Qualification, Skills & Experience

Essential Requirements:

  • PhD in immunology/stem cell/cell biology/molecular biology or another relevant field
  • Experience with molecular and cellular biology techniques
  • Strong track record of first-authored work published in reputable scientific journals
  • Willingness to work with mouse models to study human cancer xenografts and cancer cell targeting.
  • Strong teammate with the ability to work independently and collaboratively
  • Highly motivated for preclinical research in the cell and gene therapy area
  • Highly organized in lab notes, experiments, and data
  • Excellent oral and written communication skills

Desirable Requirements:

  • Hands-on experience in stem cell differentiation and immunology
  • In vivo study experience

Why Should You Apply?

This is an opportunity to work independently and in a team. Postdoc projects are generally not directly linked to pipeline projects, providing greater intellectual freedom and greater capacity to publish. You will find that AstraZeneca is well placed to support research, with an enormous depth of expertise, and a 2021 R&D spend of greater than $6 billion USD. These industry postdoc placements are designed to provide excellent training, intended to make candidates viable for careers in academia or industry.

Ready for an exciting, rewarding challenge?Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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