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Postdoc Fellow: Protein Engineering - Antibody Development

Location Gaithersburg, Maryland, United States Job ID R-118188 Date posted 02/09/2021

Location: Gaithersburg, Maryland (US)

Competitive Salary & Benefits

AstraZeneca is a global, science-led, patient-centred biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society.

About the Postdoc Program:

Bring your expertise, apply your knowledge, follow the science and make a difference.

AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to take on interesting, high impact projects in a collaborative, challenging and innovative environment.

Working with peers and professionals from diverse backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be respected as a specialist, and encouraged to speak up. You’ll lead a novel and cutting-edge research project at the interface of drug discovery and biopharmaceutical development in a multi-disciplinary scientific environment. You’ll be empowered and supported to drive the success of your project, publish papers, achieve your goals and make difference to our patients.

Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our cutting edge research laboratories and organization.

About the Opportunity:

Your project will focus on designing and developing next generation monoclonal antibodies (mAbs) that represent one of the fastest-growing class of protein therapeutics. To administer mAbs, devices such as prefilled syringes, autoinjectors, or pens have become increasingly popular as they enable self-administration by patients at home. The small injection volumes of these devices, in combination with high efficacious clinical doses for antibodies demand development of high-concentration formulations. At high concentrations, formulations often become very viscous and introduce a variety of development challenges in formulation, manufacturing, and administration of antibodies. In this project, you will apply cutting-edge protein engineering knowledge and skills to design and develop mAb therapeutics with inherently low viscosity and therefore superior development properties.

You will collaborate with motivated, innovative colleagues in team from across our state of the art R&D facilities. Drug Discovery will help you design and engineer proteins. PK/PD Labs will support testing in vivo properties. Biopharmaceutical Labs will help to characterize development properties of your designer proteins. Digital Science will work with you to develop computational tools that can guide in-silico protein development. As you can see, you’ll get great support, but your passion and drive will make the difference.

Your scientific findings will have a significant impact on biopharmaceutical development processes and platforms that are aimed at enhancing patient experience and convenience in using life-saving medicines. While making a significant contribution to bringing better medicines to life, you will also showcase your work at prestigious scientific conference and in high impact peer-reviewed journals.

Don’t miss out on this exciting opportunity to make a real scientific impact and advance your career!

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based.

Qualifications, Skills & Experience

Required:

  • PhD in structural biology, molecular biology, biochemistry, or related fields
  • Strong scientific background in the areas of protein design and engineering
  • High levels of motivation, a commitment to driving innovative science, and great problem-solving skills
  • The ability to succeed in a fast-paced, dynamic environment, and work collaboratively across functions
  • Excellent communication skills
  • Track record of peer reviewed journal publications

Desirable:

  • Protein expression, purification, and characterization skills.
  • Molecular biology with advanced PCR and molecular cloning techniques
  • Biophysical and biochemical analytical skills (e.g. ELISA, affinity measurements, dynamic light scattering, mass spectrometry)
  • Experience with in silico/computational tools to analyze protein structure

So, what’s next?

If you’re ready to put your knowledge and skills to the test, then take them further, apply today!

Advert Opens: 2nd September

Advert Closes: 3rd October



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056739 C SCGE R&D BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.