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Postdoc Fellow: Molecular Switch Engineering for Cell Therapy

Location Gaithersburg, Maryland, United States Job ID R-127190 Date posted 06/01/2022

Location: Gaithersburg, Maryland (US)

Competitive Salary & Benefits

AstraZeneca is a global, science-led, patient-centered biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society.

About the Postdoc Program

Bring your expertise, apply your knowledge, follow the science and make a difference.

Bring your expertise, apply your knowledge, follow the science and make a difference.

AstraZeneca’s Postdoc Program is for self-motivated individuals looking to tackle exciting, high impact projects in a collaborative, engaging and innovative environment. You'll work with peers and professionals from a diverse group of backgrounds, and a world class academic mentor specifically aligned to your project. We'll help you develop valuable networks which support your research and future career development!

AstraZeneca Postdocs are respected as specialists and encouraged to speak up. They lead ground-breaking drug discovery and development research projects. Our vibrant, multi-disciplinary scientific teams empower and support our Postdocs, and we encourage them to share their research at conferences, publish papers, achieve their goals and make a difference to our patients.

You'll learn from industry leaders working on innovative research across our organization.

Our Postdoc Training Program will support you to develop transferrable skills from influencing others to shape the agenda, to data analysis.

About the Opportunity

We’re currently looking for hard-working postdoctoral scientists to join our innovative academic-style Postdoc program. From our center in Gaithersburg, MD, USA, you’ll be in a global pharmaceutical environment, leading live projects right from the beginning. It’s a newly growing program spanning a range of therapeutic areas across a wide range of fields. This project strives to develop a toolbox of innovative molecular switches for improved cell therapy safety.

In this role we will make use of your experience in protein engineering and stem cell and/or T cell technologies to advance innovative molecular switch development in cell therapy by crafting and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment.

You’ll employ multiple technologies involving molecular biology, genome editing, as well as next-gen sequencing in your projects. You will apply in vitro assays to confirm the functions of newly engineered molecules and further develop animal models to validate the results.

Qualification, Skills & Experience


  • Ph.D. degree in molecular biology, bioengineering or equivalent scientific fields

  • Strong experience in molecular biology, protein engineering and cell biology

  • Experience in viral and/or non-viral vector engineering

  • Molecular biology and protein engineering skills

  • Advanced cell culture of stem cells and/or primary cells

  • In vitro assay development and optimization

  • Knowledge in Multiplex flow cytometry


  • Experience in animal handling, mouse tumor models, standard routes of dosing and engraftment

  • Experience in stem cell culture and differentiation

  • Experience in primary cell culture and expansion

  • Experience in single cell studies

Ready for an exciting, rewarding challenge? Apply today!

Advert Opens: January 7th

Advert Closes: February 7th

Where to find out more:

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants. COVID-19 vaccination is required for all US employees, and weekly PCR COVID-19 testing is required for those who are unvaccinated or have an approved accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056739 C SCGE R&D Oncology (Susan Galbraith (07016555)) (85008610)

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.