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Director, Oncology Safety Pathology

Location Gaithersburg, Maryland, United States Job ID R-118004 Date posted 10/01/2022

Are you passionate veterinary anatomic pathologist interested in driving innovation in drug discovery to bring safe and effective therapies to cancer patients? Join our team as  a Director of Oncology Safety Pathology in our Gaithersburg, MD location.

AstraZeneca discovers and develops medicines in 4 core areas of Oncology, Respiratory and Immunology (R&I), and Cardiovascular, Renal and Metabolic Disease (CVRM).  Oncology Safety, a global department within the Clinical Pharmacology and Safety Sciences (CPSS) function, is looking for Director Pathologist to join their teams to develop and advance our portfolio of innovative anti-cancer medicines in Oncology R&D.

CPSS is changing the way pathology and imaging technologies are combined to offer unprecedented insight and impact. Our pathologists are empowered by access to AI digital pathology, multiplex assays, advanced molecular imaging techniques and a full suite of in vivo imaging technologies. This position offers the opportunity for a pathologist to explore new ways of supporting how we investigate both the safety and efficacy of drugs within our projects. The role will work within a dynamic scientific team with opportunity to deliver scientific strategies that change our view of disease. This is an exciting opportunity for a passionate pathologist to shine.

As a Director Pathologist you will work at the forefront of experimental pathology and safety science, where you will help progress a rich and diverse pipeline which includes small molecules, cutting-edge mAb-based therapeutics, antibody drug conjugates, and next generation cellular and viral therapies. We are a diverse global department with Pathologists based at AstraZeneca sites in the US (Gaithersburg and Boston) and UK  (Cambridge).

You will apply your expertise in experimental and toxicologic pathology, strong communication skills and experience of successful cross-functional collaborations, both as contributor and leader, to cutting edge drug discovery and development in a multidisciplinary environment.  

As a Director Pathologist, your primary responsibilities will include:

  • Assessing safety and efficacy for a range of novel therapeutics, including antibody drug conjugates, cell based therapies, next generation Immuno-oncology, and small molecules

  • Providing expert scientific analysis for oncology portfolio safety and investigative pathology studies, including study design, interpretation and integration of pathology data, digital pathology and multi-dimensional biomarkers

  • Complex problem solving to evaluate pathological insight into disease and toxicology and develop effective capabilities and solutions that influence project decision making

  • Effectively communicate pathology findings in context with other study data in cross-functional team meetings, study reports and regulatory documents

  • Peer review of outsourced non-GLP and GLP toxicology studies

  • Supporting discovery research programs by providing comparative molecular pathology expertise to projects, in vitro systems and in vivo models


  • DVM and ACVP or ECVP board certification in Veterinary Anatomic Pathology

  • PhD in a relevant scientific discipline is strongly preferred

  • 5+ years of experience in pharmaceutical drug development with proficiency in toxicologic pathology

  • Experience with novel drug modalities including antibody drug conjugates, cell and viral based therapies and oligonucleotides

  • Ability and ambition to take on leadership roles

  • Excellent communication and interpersonal skills

  • Ability to work independently and collaboratively in an inclusive and dynamic, team-oriented environment

  • Experience with molecular pathology assay development, data integration and analysis, and enthusiasm to champion digital pathology and machine learning driven artificial intelligence

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants.  COVID-19 vaccination is required for all US employees, and weekly PCR COVID-19 testing is required for those who are unvaccinated or have an approved accommodation.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056669 F CDPN R&D BioPharmaceuticals

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.