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Associate Scientist / Scientist, Cell Culture & Fermentation Sciences

Location Gaithersburg, Maryland, United States Job ID R-134288 Date posted 26/03/2022

Associate Scientist / Scientist, Cell Culture & Fermentation Sciences

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.  This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. 

Summary of the group:

The Biopharmaceutical Development (BPD) group is a multi-disciplinary scientific function providing expertise in process/analytical/formulation/devices development and characterization with integrated bioprocess engineering, clinical manufacturing, and supply chain and logistics operations. The group is also responsible for transferring the processes to different commercial sites in and outside the AstraZeneca organization. BPD is present in multiple sites including Gaithersburg, MD and Cambridge UK.

The Cell Culture and Fermentation Sciences (CCFS) Group is accountable for designing, developing, optimizing, and validating cell culture and fermentation processes for a wide range of biologic products. The group generates optimal cell lines and is also responsible for technology transfers into manufacturing and preparing CMC documentation for regulatory submissions. Cutting edge high throughput scale-down models are employed to develop high-performing media and processes to support production. The group actively implements novel technologies, including automation and analytics, to advance production platform capabilities and drive forward a diverse exciting project portfolio.

Main Duties & Responsibilities:

This position within Cell Culture and Fermentation Sciences will involve a substantial amount of hands on cell culture work to develop, scale up, and characterize mammalian culture processes. Major responsibilities include:

  • Design and execute shake flask and small-scale bioreactor experiments to support process development, including media/feed optimization and scale up/scale down modelling.
  • Perform analytical testing to characterize mammalian cells.
  • Perform technical transfer activities and manufacturing support for the clinical/commercial process.
  • Make detailed observations, analyze data, and interpret results to contribute to “go/no go” decisions and convey these findings effectively in laboratory notebooks, technical reports, and presentations.
  • Participate in various cross-functional technology development and pipeline teams, demonstrating a strong ability to collaborate and communicate with others.
  • Present at internal departmental and cross-functional meetings; may participate in/present at external scientific meetings.

Education & Experience Requirements:

Bachelor’s or master’s degree in chemical/biochemical engineering, biotechnology, biochemistry, or biological sciences.

Associate scientist: Bachelor’s or Master’s degree with 0+ years of experience

Scientist: Bachelor’s degree with 5+ years or Master’s degree with 2+ years of related experience in industry or academia

Required Skills:

  • Strong background in bioprocessing
  • Strong background in experimental design, statistical analysis, and process modeling
  • Ability to work both independently and within teams
  • Ability to multitask and handle multiple priorities in a fast-paced environment
  • Aseptic technique
  • Cell culture activities may require periodic weekend work.

Desired Skills:

  • Candidates with prior experience with mammalian bioreactors will be preferred
  • Strong background in cell metabolism
  • Programming in Python, MATLAB, R, or other scientific language

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Check out our landing page for more information on our BPD group

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056739 C SCGE R&D BioPharmaceuticals

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.