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Associate Scientist, Purification Process Sciences

Location Gaithersburg, Maryland, United States Job ID R-121822 Date posted 17/10/2021

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.  This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. 

Summary of the group:

In Purification Process Sciences in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.  We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

Main Duties & Responsibilities:

The position resides in the Purification Process Sciences group (PPS) within the Bioprocess Development  R&D (BPD) department. Members of the PPS function work closely with other development functions and manufacturing sciences to develop and transfer clinical and commercial purification processes. Position may require weekend work and/or periodic late-nights. 

Main duties are as follows:

  • Design, development, and optimization of downstream processes for the manufacture of biopharmaceuticals in early and late stage development.

  • Evaluation and development of new technologies to facilitate process development and increase purification process efficiency.

  • Performing purifications for complex biopharmaceutical drugs such as antibodies, bispecific antibodies, fusion proteins, pDNA, and viruses

  • Performing studies to develop scalable purification processes and assist is tech transfer activities

  • Solving challenging protein purification problems

  • Coordinating closely with the research department, cell culture group, and analytical biotechnology group in order to meet project timelines and company goals

  • Conducting pilot scale purifications in support of process development activities and PK/PD studies

  • Reviewing, Analyzing, and interpreting analytical and process data

  • Maintain accurate records of data and actively participate in laboratory organization

  • Professionally deliver results to internal and external audiences

  • Should be able to function with limited supervision and is expected to work independently on a day-to-day basis. Expected to design and execute experiments with minimal supervision. Expectation for independence will increase with time and experience in the position.

Relevant Education & Experience Requirements:

BS/BA or MS/MA biology, biochemistry, chemical/biochemical engineering, or related field

A minimum of a BS/MS and 0+ years of experience required, some relevant experience preferred

Required Skills and/or experience:

  • Highly team-oriented, energetic, critical thinker, organized, capable of multitasking with excellent oral and written skills

  • Biotechnology oriented coursework (e.g. biochemistry, biology, genetics, etc.)

  • Proficiency with basic laboratory technique gained through prior employment, internships, or coursework

  • Proficiency with MS Office and Excel

  • Knowledge of

    • Basic Protein Chemistry

    • Protein Chromatography

    • Biotechnology fundamentals

    • Data analysis and statistics

Desired Skills and/or experience:

  • Experience performing protein chromatography using Akta/Akta software

  • Experience performing analytical testing and HPLC analysis

  • Purification Process Design for protein therapeutics

  • GLP/GMP experience

  • Protein Modification by Conjugation and PEGylation

  • Troubleshoot and collaboratively resolve complex problems under tight time constraints

  • Knowledge of

    • Membrane based separations, Tangential flow filtration (TFF) and depth filtration

    • Basic Analytical Techniques (HPLC and SDS-PAGE Analyses)

    • DOE techniques and software

    • Viral Clearance

    • Purification process design for monoclonal antibodies, bispecifics, Fabs, and other novel formats 

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.