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Associate Director in Bioanalysis: Cell-based immunologic assay specialist with molecular-based techniques

Location Gaithersburg, Maryland, United States Job ID R-121564 Date posted 13/10/2021

Associate Director in Bioanalysis: Cell-based immunologic assay specialist with molecular-based techniques experience

Do you have expertise in cell-based flow cytometry and molecular-based qPCR/qRT-PCR development? Would you like to apply your expertise to impact multiple programs in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, willing to collaborate, and curious about what science can do, then you’re our kind of person. We are seeking a highly skilled and motivated Ph.D. scientist with strong immunology, cell biology and molecular biology background to join our group within Integrated Bioanalysis in Gaithersburg, MD. The position will take a lead role in developing and implementing bioanalytical strategies for advancing our drug pipeline and working as the group representative in multidiscipline drug development teams.

The candidate will work in our Integrated Bioanalysis Department, which is part of the Clinical Pharmacology and Quantitative Pharmacology Group, and be responsible for providing high quality, decision-driving data using a variety of platform and novel technologies. Our team primarily focusses on early R&D pre-GLP bioanalyses along with exploratory biomarkers assessments across all therapeutic areas. We have a diverse array of scientists working across different technologies to ensure delivery of critical assays, and data analysis that drive go/no-go decisions and ensure the accurate combination of medicines get to the correct patient, in the right dose, and at the right time!

What you’ll do

  • Develop and implement bioanalytical strategies to support drug programs (e.g., Oncology, Respiratory and Immunology, Cardiovascular, Renal and Metabolism) from lead candidate selection through clinical trials.
  • Lead bioanalytical strategies for the CART and gene therapy programs.
  • Lead CART and gene therapy pharmacokinetics, pharmacodynamics and biomarker activities in the lab to better understand drug actions and their associations with clinical response.
  • Design, develop and interpret cell-based flow cytometry, molecular-based assays.
  • Represent the department on multidiscipline drug development teams, thus ability to support technologies, especially cell-based functional flow and molecular-based assays will be a benefit.
  • Supervise associate(s)/scientist(s) and take a lead role in pushing the boundaries in determining lead drug candidates and facilitating global clinical trials.

Crucial for the role

  • Ph.D. in immunology, cell and molecular biology, or other related scientific fields and post-doctoral experience in related areas.
  • Strong background in immunology, cancer biology and experience with diverse immunologic assays and molecular techniques (qPCR, qRT-PCR).
  • 7-10 years of experience in academia or industry coming from projects that developed sophisticated immune cell function and molecular-based (e.g., human T cell, flow cytometry, RNA) assay development and data interpretation skills.
  • A high level of independence and with an ability to develop hypotheses and implement analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.
  • Attention to details, good communication and collaboration skills. Outstanding record-keeping skills are crucial for success.
  • Think and act creatively, independently, and within teamworks.

Desirable for the role

  • Experience with molecular techniques and applications for gene-editing, anti-sense, oligonucleotide, RNA technology and delivery system.
  • Experience with sophisticated data analysis tools for analyzing and visualizing biomarker data (highly valued).
  • Experience with broader Immunoassays e.g. ELISA, multiplex assays, Elispots etc.
  • Knowledge of GxP regulations.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056733 E SCPY R&D BioPharmaceuticals

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.