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Postdoc Fellow – The Response of Human Airway Mucosa to Virus

Location Cambridge, England, United Kingdom Job ID R-076950 Date posted 05/28/2020

Postdoc Fellow – The Response of Human Airway Mucosa to Virus

Cambridge, UK

Competitive Salary on Offer

About the Postdoc Program:

We’re currently looking for talented scientists to join our innovative academic-style postdoctoral programme. From our centre in Cambridge, UK, you will from the start, engage and connect across a global pharmaceutical environment, contributing to live projects spanning a rand of therapeutic areas and disciplines. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About the Opportunity:

This project aims to understand the mechanisms by which the airway mucosa fights against viral infections. These mechanisms might be altered in asthma patients favouring undesirable viral exacerbations.

We are seeking a highly motivated Post-Doctoral Fellow to join the Early Respiratory and Immunology research group in Cambridge, UK to work on a collaborative research project investigating the role of the airway mucosa in viral infection and altered anti-viral responses in chronic airway diseases. You will focus your postdoctoral research on characterising novel biological pathways in the mucosa active during viral infection and their dysregulation in chronic inflamed airways utilizing state-of-the-art Omics approaches. The research will be conducted in AstraZeneca laboratories and will help drive innovation in those scientific areas of particular interest to AstraZeneca in achieving our vision to advance science and medicine to help people live better lives.

What could be more inspirational than that?

Your research will utilize state-of-the-art single cell transcriptomic and proteomic technologies to build the first comprehensive mechanistic landscape of the airway mucosa in health and asthmatic disease following viral infection. We need a scientific professional to drive the application of data science methodologies to analyse single cell transcriptomics and proteomics and integrate into a coordinated mechanistic biology understanding. If this is sounds like your next scientific challenge, apply now!

Essential Education and Experience:

  • Ph.D. or post-doctoral research in immunology, biological sciences or a closely related field.
  • Demonstrated Ph.D. or post-doctoral research with ability to work independently as well as collaboratively within a team to conduct a high-level research project.
  • A deep understanding and technical expertise in analysis of omics data, bioinformatics and computational biology methodologies, with spatial focus in single cells transcriptomics
  • Hands-on experience with laboratory based single cell RNA sequencing
  • A fundamental understanding of the biological systems and signalling involved in human disease.
  • Demonstrated enthusiasm to explore non-traditional approaches to bring big data together in biologically meaningful ways.
  • Strong written and oral communication skills, ability to make effective presentations and demonstrate critical analyses of data sets
  • Excellent publication record is essential (project is expected to yield publication of scientific results in peer-reviewed journals).

Desirable Qualifications:

  • Understanding of relevant biology e.g. respiratory disease, or mucosal biology, or virology
  • Experience in cell biology and protein expression analyses
  • Expertise in development of novel statistical approaches for the analysis of biological data
  • Networked within external bioinformatics communities
  • Effective contributing to collaborative projects involving cross-disciplinary and global teams
  • Awareness of graph modelling, machine learning, artificial-intelligence

About AstraZeneca                   

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

This is a 3-year programme.  2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based.  The role will be based in Cambridge, UK, with a competitive salary on offer 

Advert opening date – May 28, 2020

Advert closing date – July 4, 2020



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.