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Occupational Toxicology Lead

Location Cambridge, England, United Kingdom Macclesfield, England, United Kingdom Job ID R-142710 Date posted 05/07/2022

Occupational Toxicology Lead

Competitive salary and benefits apply

Location: UK (Macclesfield or Cambridge) Sweden (Sodertalje or Gothenburg)

Leads the Occupational Toxicology area within Global Safety, Health and Environment (SHE), developing the overall strategy for occupational toxicology and providing the global business with toxicological expert advice and support for work place health risk assessments, ensuring scientific quality and compliance with internal SHE requirements, laws and regulations in all countries.

Typical Accountabilities

  • Lead a team of global experts supporting the business with problem-solving in all aspects of occupational toxicology and hazard/risk assessments.

  • Oversee the AZ Global Panel for OEL/PDE to ensure the achievement of near-term deliverables and strategy to meet long term business demands.

  • Establish health-based exposure limits and author documentation for regulatory compliance, including Permitted Daily Exposures (PDEs) to support of product quality (e.g. cleaning validation and product excursions encountered in large and small bio/pharmaceutical manufacturing) and worker health and safety activities (e.g., occupational exposure bands and limits (OEBs and OELs)).

  • Provide toxicology support for nonclinical safety assessment (regulatory/project toxicology) groups with requests from project teams, development and toxicology leads.

  • Provide expert technical advice and prepare toxicology assessments in support of health hazard classification for Safety Data Sheets according to GHS and CLP, and Dangerous Goods to support worker safety as well as general public in support of chemical notification/registration (i.e., EU (REACH), China, etc.).

  • Provide robust, scientifically-sound risk management processes to support health hazard assessment for: employees handling proprietary and non-proprietary chemicals used in the production of medicinal products in the workplace and product quality activities (primarily associated with manufacturing).

  • Manage occupational testing programs in compliance with evolving global and company regulations and guidance.

  • Provide technical and scientific support for setting limits for releases into the aquatic environment.

  • Maintain toxicological expertise relevant to nonclinical safety of drugs, occupational health, and product quality risk, i.e. keeps up to date with the scientific literature and regulatory guidance, attends and contributes to relevant professional/scientific meetings, and publishes in peer reviewed journals, if appropriate.

Essentials

  • PhD in toxicology or related biomedical science field.

  • Professional Business Qualification/Certifications

  • Seven+ years of experience in senior strategic Safety, Health and Environment covering roles in both Pharmaceutical and Biologic businesses. 

  • Proven proficiency in technical science writing, specifically in regard to chemical monographs for risk assessment.

  • Experience in both occupational (e.g. worker exposure) and quality (e.g., patient safety) toxicology assessments.

  • Familiar with regulations and guidelines for both worker and patient safety

  • Applied, working knowledge of the general principles, practices and procedures of multiple facets including pharmacology, toxicology, biology, and chemistry and the relationship between toxicological, physical, and chemical properties of small and large molecule pharmaceuticals and biologics.

  • Excellent written and verbal communication skills as well as proven negotiation, collaboration and interpersonal leadership skills.

  • Significant experience in people management and networking in a matrix organisation

  • Ability to influence strategically and persuade tactfully, to obtain desired outcomes while maintaining effective, positive, organizational relationships.

  • Good appreciation of SHE processes and policies, and have senior management, consultancy or advisory experience in influencing strategy

Desirable

  • Familiarity with the latest research and thinking in specialist areas.

  • Excellent knowledge of AstraZeneca policies, Standards, Procedures and Guidelines

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and spark your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours

Where can I find out more?

Our Social Media,

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Opening Date: 06/07/2022

Closing Date: 08/08/2022

10000075 F HSMG Global Sustainability

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.