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Director, Statistical Science

Location Cambridge, England, United Kingdom Wilmington, Delaware, United States Gaithersburg, Maryland, United States Macclesfield, England, United Kingdom Job ID R-117127 Date posted 24/11/2021

Director Statistical Science, Supervisor – Global Medical Affairs/Payer Biometrics

Locations: Cambridge or Macclesfield (UK) Gaithersburg or Wilmington (Delaware) (US)

Competitive salary and benefits package on offer

Do you have a passion for science, statistics and leadership? Are you up for the challenge to impact a company that follows the science and turns ideas into life changing medicines? If yes, we welcome you to join AstraZeneca!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide, while applying leading edge approaches to science across many business areas. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to act, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

We hope that you are our new Director Statistical Science (Supervisor) who can join us to play an important part in our growing Global Medical Affairs/Payer Biometrics statistics group which sits within Oncology Biometrics. This role combines individual statistical design and strategic contributions with the opportunity to lead, manage, and develop a small group of Statisticians.

The Director Statistical Science (Supervisor) reports to the Head of GMA/Payer Biostatistics and will be responsible for the delivery of services to the groups two key stakeholders, GMA and Oncology Market Access and Pricing (OMAP). For GMA, the group provides statistical support for interventional and Real World Evidence (RWE) studies, including developing design options and providing high quality decision support. For OMAP, the group provides statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration, including contributing to Health Technology Assessment (HTA) submissions.


What you will do:


As aDirector Statistical Science (Supervisor) you will line manage and develop a team of statisticians. You will be expected to:

  • Take on a leadership role and drive statistical thinking in cross-functional team projects

  • Lead, manage, and develop a global group of statisticians, ensuring the successful delivery of projects while also considering the development needs of the team

  • Contribute to strategic planning and quantitative decision making

  • Participate in adapting and developing statistical methodology

  • Contribute to development of new procedures and standards to increase quality, efficiency, and effectiveness

  • Influence key stakeholders and governance

  • Act as a technical expert in interactions with external providers and collaborators 

  • Work with regulatory and payer agencies, e.g. attending meetings, answering questions

  • Provide mentoring to more junior staff and present at internal training seminars

Desirable qualifications and experience:

  • MSc or Ph.D. Statistics, Biostatistics, or Mathematics (containing a substantial mathematical component).  

  • Experience of leading projects and people in a pharmaceutical or CRO environment.

  • Publication experience and/or experience of presenting at external meetings (e.g. ISPOR, PSI)

  • Programming expertise in R, WinBugs and/or SAS.

  • Experience of reimbursement submissions in key markets (e.g. UK and Germany.).

  • Regulatory submission experience in key markets (e.g. EU and USA.) 

  • Application of indirect comparison methodology (e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).

  • Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCW methodology.).

  • Analysis of health utility data including mapping and value set application.

  • Application of causal inference models to clinical trial and RWE data.

  • Experience of working with RWE datasets and registries (e.g. Flatiron.).

Why AstraZeneca?


It’s a place to think differently – to find new ways of handling and treating diseases. We are trusted and empowered to explore. Ultimately, it’s more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That’s what drives us – the potential to impact over one billion patients worldwide.

So, what’s next! If this sounds like your next challenge - apply today! We look forward to get to know you better. Welcome to send us your application through our website at your earliest convenience, but no later than 25th January 2022

For more information about these positions, please contact Owain Saunders at owain.saunders1@astrazeneca.com


Where can I find out more?


Follow AstraZeneca on Instagram: https://www.instagram.com/astrazeneca_careers/?hl=en

Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

Please visit our Biometrics landing page: https://careers.astrazeneca.com/biometrics



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056650 F CDBT R&D Oncology (Susan Galbraith (07016555)) (85008610)

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.