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Biometrics Team Leader/Director – Global Medical Affairs/Payer Biometrics

Location Cambridge, England, United Kingdom Gaithersburg, Maryland, United States Job ID R-097589 Date posted 01/15/2021

Biometrics Team Leader/Director – Global Medical Affairs/Payer Biometrics

Location Cambridge, England, United Kingdom or Gaithersburg, Maryland, US

Salary: Competitive salary

At AstraZeneca every one of our employees makes a difference to patient lives every day. Each and every one of us believes that science has the ability to change lives and that to deliver this takes many people with many skill sets. When we deliver a life-changing medicine, that success comes from the combined efforts of all of our people.

We are currently looking for a Biometrics Team Leader/Director to lead, manage (if appropriate) and develop a group of statisticians who work within our Global Medical Affairs (GMA) and Payer Biometrics statistics group which sits within Oncology Biometrics.

The Biometrics Team Leader/Director reports to the Head of GMA/Payer Biostatistics and is accountable for operational planning and delivery of services to the groups two key stakeholders, GMA and Oncology Market Access and Pricing (OMAP). For GMA, the group provides statistical support for interventional and Real World Evidence (RWE) studies, including developing design options and providing high quality decision support. For OMAP, the group provides statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration, including contributing to Health Technology Assessment (HTA) submissions.

Main duties and responsibilities

The main duties and responsibilities of the role will include;

  • To lead, manage and develop a group of statisticians, ensuring the successful delivery of projects while simultaneously considering the development needs of statisticians.

  • Efficiently utilize resource in the group and beyond to deliver key projects to time, quality and within resource constraints.

  • Design and analysis of interventional and non-interventional studies (incl. sample size estimation and randomisation specification.) 

  • Developing statistical analysis plans for complex studies and/or project deliveries.

  • Contributing to protocols, clinical study reports, regulatory documents and manuscripts. 

  • Providing support to the payer function for late stage oncology assets. Including post hoc analysis of clinical trial data to support development of cost effectiveness and budget impact models.

  • Representing AstraZeneca to Health Authorities and Reimbursement & Payer Organizations for specific projects

  • Analysis of published literature and RWE sources (e.g. network meta-analysis and synthetic control arms).

Desirable qualifications and experience:

  • MSc or Ph.D. Statistics, Biostatistics, or Mathematics (containing a substantial mathematical component).

  • Extensive experience in drug development, study design, and data analysis and interpretation.  

  • Experience of leading projects and people in a pharmaceutical or CRO environment.

  • Publication experience and/or experience of presenting at external meetings (e.g. ISPOR, PSI)

  • Programming expertise in R, WinBugs and/or SAS.

  • Experience of reimbursement submissions in key markets (e.g. UK and Germany.).

  • Regulatory submission experience in key markets (e.g. EU and USA.)  

  • Application of indirect comparison methodology (e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).

  • Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCW methodology.).

  • Analysis of health utility data including mapping and value set application.

  • Application of causal inference models to clinical trial and RWE data.

  • Experience of working with RWE datasets and registries (e.g. Flatiron.)

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a phenomenal fit, please share this posting with them.

Where can I find out more?

Date open: 15th January 2021

Date closed: 15th February 2021

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.