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Associate Director, Translational Medicine, Oncology – DNA damage response

Location Cambridge, England, United Kingdom Job ID R-105670 Date posted 29/04/2021

Do you have expertise in, and a passion for delivery of scientifically-driven biomarkers in drug discovery and development programs for targeted agents within DNA damage response? would you like to apply your expertise to impact an industry-leading portfolio of targeted therapy programs from inception through to life cycle management for marketed drugs  in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

This position is based in Cambridge and will involve some travel to AstraZeneca sites in Cambridge and London.

Cambridge Science Park is one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site and park provides for you… After-work events, Lunch & Learns, Bright and spacious environment, Sustainable office working environment, Onsite Childcare, Networking events, Park site Hair & Beauty Salon, Gym and Restaurants.

Business area

From diagnosis to later stage development, we’re laser-focused on leading the way forward to create solutions that transform lives. We are focused on identifying and treating patients earlier, where there is greater curative potential. With the greatest number of early stage cancer trials in the industry, we are getting closer to finding cures every day.

It is the breadth and strength of our innovative pipeline that offers both security and stability. And with the goal to deliver 6 new molecular entities by 2025, it’s up to each of us to keep pushing our industry-leading Oncology pipeline forward and build the future

What you’ll do

In this role you will be accountable for leading delivery of robust, scientifically-driven biomarkers in drug discovery and development programs for targeted agents in DNA damage response.  You will have the opportunity to impact an industry-leading portfolio of targeted therapy programs from inception through to life cycle management for marketed drugs. 

  • Developing biomarker strategies and ensuring delivery within oncology project teams.
  • Delivering biomarkers for clinical studies based on the best available science and technologies.
  • Generating disease linkage data to guide indication selection and targeted patient populations.
  • Measuring target engagement reliably and quantifiably to inform clinical decisions for selecting   therapeutically relevant doses and schedules.
  • Understanding key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
  • Defining novel mechanisms of resistance targeted therapies by studying tumors at relapse.

Essential for the role

  • PhD and/or MD with extensive experience in drug development
  • In-depth knowledge of oncology disease area biology and translational science, with expertise in DNA damage response biology
  • Proven communication and influencing skills.
  • Highly developed problem solving and risk management skills.
  • Highly developed collaborative working skills.
  • Ability to act as an external ambassador and to influence external organisations to enhance the image and reputation of AstraZeneca.
  • Proven ability to motivate and develop others.

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 10/05/2021

Where can I find out more? Our Social Media,

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

10001103 F SCTS R&D Oncology (Pascal Soriot (08126850) (Inherited)) (85008610)

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.