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Biometrics Team Leader/Director – Global Medical Affairs/Payer Biometrics

Location Cambridge, England, United Kingdom Gaithersburg, Maryland, United States Job ID R-097589 Date posted 13/04/2021

Biometrics Team Leader/Director – Global Medical Affairs/Payer Biometrics

Location Cambridge, England, United Kingdom

Salary: Competitive salary

Do you have expertise in, and passion for, Biometrics? Would you like to apply your expertise to impact Global Medical Affairs in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for

some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies.

Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we are aiming to deliver 6 new molecular entities by 2025.

We are currently looking for a Biometrics Team Leader/Director to lead, manage (if appropriate) and develop a group of statisticians who work within our Global Medical Affairs (GMA) and Payer Biometrics statistics group which sits within Oncology Biometrics.

The Biometrics Team Leader/Director reports to the Head of GMA/Payer Biostatistics and is accountable for operational planning and delivery of services to the groups two key stakeholders, GMA and Oncology Market Access and Pricing (OMAP). For GMA, the group provides statistical support for interventional and Real World Evidence (RWE) studies, including developing design options and providing high quality decision support. For OMAP, the group provides statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration, including contributing to Health Technology Assessment (HTA) submissions.

Main duties and responsibilities

The main duties and responsibilities of the role will include;

  • To lead, manage and develop a group of statisticians, ensuring the successful delivery of projects while simultaneously considering the development needs of statisticians.
  • Efficiently utilize resource in the group and beyond to deliver key projects to time, quality and within resource constraints.
  • Design and analysis of interventional and non-interventional studies (incl. sample size estimation and randomisation specification.) 
  • Developing statistical analysis plans for complex studies and/or project deliveries.
  • Contributing to protocols, clinical study reports, regulatory documents and manuscripts. 
  • Providing support to the payer function for late stage oncology assets. Including post hoc analysis of clinical trial data to support development of cost effectiveness and budget impact models.
  • Representing AstraZeneca to Health Authorities and Reimbursement & Payer Organizations for specific projects
  • Analysis of published literature and RWE sources (e.g. network meta-analysis and synthetic control arms).
  • Dependent on experience, mentoring of more junior staff and presenting at internal training seminars.

Desirable qualifications and experience:

  • MSc or Ph.D. Statistics, Biostatistics, or Mathematics (containing a substantial mathematical component).
  • Extensive experience in drug development, study design, and data analysis and interpretation.  
  • Experience of leading projects and people in a pharmaceutical or CRO environment.
  • Publication experience and/or experience of presenting at external meetings (e.g. ISPOR, PSI)
  • Programming expertise in R, WinBugs and/or SAS.
  • Experience of reimbursement submissions in key markets (e.g. UK and Germany.).
  • Regulatory submission experience in key markets (e.g. EU and USA.)  
  • Application of indirect comparison methodology (e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).
  • Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCW methodology.).
  • Analysis of health utility data including mapping and value set application.
  • Application of causal inference models to clinical trial and RWE data.
  • Experience of working with RWE datasets and registries (e.g. Flatiron.)

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

    AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

    10001007 G CDBT R&D Oncology (Pascal Soriot (08126850) (Inherited)) (85008610)

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