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Associate Principal Scientist – Formulation Early Product Development and Manufacturing

Location Macclesfield, England, United Kingdom Job ID R-095579 Date posted 18/01/2021

Associate Principal Scientist – Formulation Early Product Development and Manufacturing

Macclesfield, UK

Salary & Benefits Competitive

At AstraZeneca, we believe in the potential of our people and you’ll develop beyond what you thought possible! We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.

Pharmaceutical Sciences is a department within our Biopharmaceuticals R&D organisation. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, synthetic route design and manufacturing of Active Pharmaceutical Ingredients (API) and formulated products. Our portfolio of projects includes a broad range of small and large synthetic molecules, from different drug modality classes, utilised in treatments across AstraZeneca’s therapy areas.

Job Description

We are looking for a hardworking and highly capable Associate Principal Scientist to join our Early Product Development and Manufacturing (EPDM) team in Macclesfield, UK. As a Formulation Scientist in EPDM, you will be responsible for supporting the design of drug delivery systems for clinical studies. You will work closely with analytical, manufacturing, biopharmaceutics and solid-state scientists in EPDM as well as external partners to ensure all the goals are met.

Main Duties and Responsibilities:

  • Drive/Support scientific product design, process and/or product performance understanding to influence strategies in early product development with line of sight to the late stage development
  • In-depth knowledge to characterize physical attributes of APIs and formulated dosage forms
  • Formulate APIs into conventional, enabling and sustained release dosage forms for oral administration.
  • Lead all aspects of pharmaceutical development and cGMP manufacturing of Drug Products at CMOs and acts as primary scientific contact to deliver the project to time and to budget
  • Demonstrate scientific leadership for formulation area and deliver improvements through coaching and mentoring of others individually and through the skill area networks
  • Track record of authoring high quality regulatory submissions for IND/IMPD
  • Plan/conduct the experimental work either in-house or together with the CMOs to achieve efficient products ready for scale-up to clinic
  • Proactively bring scientific insight into drug projects, improvement projects and drive evaluation of new technology/processes through internal or external collaboration
  • Ensures own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards
  • Contribute to the technical development of other scientists
  • Keep abreast with the scientific literature and proactively apply existing and novel approaches to projects
  • Publish novel work in peer reviewed journals

Qualifications and Experience:

  • Degree (preferably Masters or PhD) in Pharmaceutical Sciences or a related subject
  • Leader and is at forefront in the scientific subject area of formulation
  • Strong track record of formulating and characterising a variety of dosage forms, for example, conventional immediate release tablets and capsules, amorphous solid dispersions, nanoparticles and lipid-based delivery systems
  • Preferred experience in Parenteral formulation development
  • Experience in management of outsourced activities at CMOs
  • Track record as a scientific leader, providing scientific challenge and direction to colleagues
  • In depth understanding of how the physicochemical and solid-state properties of the drug, dosage form and route of administration affect the rate and extent of absorption
  • Experience in building mechanistic understanding of the drug delivery system performance in vitro and linking it to in vivo performance
  • Experienced in developing and applying predictive tools to aid product design

Skills and Capabilities:

  • Proven track record of problem solving and hands-on experience from years in the laboratory working on the development of dosage forms for early clinical studies
  • Ability to handle several projects at the same time, using initiative and imagination to meet agreed objectives and timelines
  • Good team working and networking skills and an ability to engage relevant AstraZeneca staff in new initiatives
  • Be visible and accessible - be the ‘go-to’ person in their area of expertise
  • Ability to mentor peers for enhanced individual and team performance and development
  • A track record of establishing mutual respect, trust, and close collaborations with internal and external organizations, and the ability to interact optimally at all levels
  • Global mindset and ability to work across multiple geographical locations. Ability to work with and through others
  • Demonstrate a high degree of personal credibility

Next Steps – Apply today!

Open Date 17/12/2020

Close Date 31/01/2021

To be considered for this exciting opportunity, please complete the full application on our website. If you know someone who would be a phenomenal fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056729 E SCPE R&D BioPharmaceuticals

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