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Senior Scientist In Vivo Pharmacology - Immuno Oncology

Location Cambridge, England, United Kingdom Job ID R-072694 Date posted 06/24/2020

At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of

organisation to reset expectations of what a bio-pharmaceutical company can be.

This means we’re opening up new ways to work, exploring state of the art methods and

bringing unexpected teams together. AstraZeneca wants to redefine the cancer-treatment

paradigm, and we seek to bring six new cancer medicines to patients by 2020.

Our Oncology core drug development expertise is at the heart of our three-dynamic scientific centres in Cambridge (UK), Boston (US) and Gaithersburg (US). AstraZeneca's broad pipeline of next-generation oncology medicines is focused principally on four disease areas – breast, ovarian, lung and haematological cancers. Are you ready to work on one of the most exciting pipelines in the Oncology industry?

We are seeking a highly motivated Senior Scientist with good in vivo and in vitro expertise and knowledge of tumour models and immunology to join our Oncology Research Team.

In this role, you will play a pivotal role in isolating therapeutic antibodies and developing our expertise in immuno-oncology.

You will be based at the Cambridge Biomedical Campus and Granta Park sites in

Cambridge (UK).

Main Duties and Responsibilities

You will spend the majority of time in the laboratories within the Oncology Research group, and you will support projects aligned with one of AZ Oncology’s key focus areas,

immuno-oncology. You will focus on develop, design, run and analyse in vivo, ex vivo, and in vitro experiments to understand the effect of drugs in complex model systems. You will bring expertise in in-vivo techniques and will perform studies using in vivo tumor models. You may also perform in vitro immune assays with primary cells (human or murine) to support projects in the immuno-oncology pipeline and in vitro assays using cultured cell lines (e.g. luciferase reporter cell assays).

You will also provide support for tumour studies such as tissue acquisition for ex vivo analysis (e.g. confocal microscopy and flow cytometry), to understand the effect of test substances in complex preclinical models and immunology experiments relevant for cancer immunotherapy. Moreover, you will have a strong expertise in techniques for the analysis of immune function and phenotype (e.g. flow cytometry, proliferation, cytokine/chemokine release [e.g. MSD, ELISA], chemotaxis, target cell killing assays) and actively keep up to date with new

technological developments.

Essential Requirements

  • PhD (or equivalent) in a biological science with significant hands-on in vivo experience OR BSc /MSc (or equivalent) plus equivalent experience in scientific discipline such as immunology or cancer research.
  • Hands-on experience with animal handling and procedures including dissection and tissue collection or running in vivo models, particularly oncology models.
  • Understanding and enthusiasm for tumour immunology and cancer therapies.
  • Possession of a range of in vitro skills that can be applied to cancer immunology research. This includes tissue culture techniques for cell-based immunoassays, experience working with human immune cells, ex vivo immunobiology techniques such as: complex flow cytometry (including intracellular cytokine or multicolor cell surface staining); MSD; and ELISA.
  • Data processing, statistical analysis and interpretation.
  • Experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).
  • Willingness to work flexibly; including weekends if necessary.

Desirable Requirements

  • Experience working in the field of immune-oncology within the pharmaceutical or biotechnology industry, or in academia.
  • Home Office Licence (Modules 1-4) or equivalent qualification for animal work and experience working under Home Office Regulations (as a Personal Licence Holder)
  • Publications in top-tier scientific journals
  • Molecular biology skills including transcriptomics, assessment of intracellular signaling and generation of engineered cell lines
  • Experience of supervising or mentoring.

Next Steps – Apply Today!!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience. It is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

Closing date for applications: 17th July 2020

Apply Today!



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.