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Postdoc Fellow - BRCA2 complexes by EM

Location Cambridge, England, United Kingdom Job ID R-072717 Date posted 02/18/2020

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technological experts in the industry, all collaborating on high-profile drug discovery projects.

This is an opportunity for a talented and self-motivated scientist to undertake biophysical and structural studies of macromolecular complexes between BRCA2 and other tumour suppressor proteins. You’ll have access to state-of-the-art cryoEM and biophysics infrastructure with a leading structure and biophysics group and work in close collaboration with Prof Ashok Venkitaraman’s group at the MRC Cancer Unit.

For this role you’ll be expected to:

• Prepare and characterise protein complex samples

• Optimise cryo-EM data collection conditions

• Perform cryo-EM structure determination

• Integrate information from structural & biophysical studies to create structural models

• Present your results at scientific conferences and publish credible papers in peer reviewed journals

Education and Experience required:


• A PhD in Structural Biology or Biochemistry, supported by an understanding of protein structure and biochemistry

• Expertise in protein expression, purification and biochemical characterization and in biophysical and structural techniques

• Experience in integrative structural biology


• Expertise in biophysical techniques for studying protein structure or molecular complexes, such as cryo-EM or X-ray crystallography

• Expertise in assembling/handling/characterizing large protein-protein complexes

• Expertise in non-recombinant protein purification

Skills and Capabilities required:

• Excellent organizational, collaboration and communication skills

• Creativity and a drive for excellence, as demonstrated by a credible history of publication

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based in Cambridge, UK, with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 18th Feb 2020 / Advert closing date – 31st March 2020

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.